Protective mechanisms of berberine against experimental autoimmune myocarditis

Berberine, an alkaloid derivative extracted from numerous plants of the general Berberis and Coptis, has been reported to have immunomodulatory effects against immune-mediated disorders in emerging studies. In this study, the effects of berberine and its underlying molecular mechanisms were investigated from the myosin-induced myocardial injury in rats. Lewis rats were immunized with porcine cardiac…

Pacritinib put on FDA hold

The trial drug pacritinib (in development by CTI BioPharma) has been placed on full clinical hold by the FDA due to concerns over the safety of the drug. Analysis of data from clinical trials that were ongoing show a detrimental effect on survival and patient deaths from causes including intracranial hemorrhage, cardiac failure and cardiac…

7th International Conference on Myeloproliferative Neoplasms

Summary Over the past few years there has been a flood of new insights into the classification, pathogenesis and management of MPNs. This international conference brings together scientists and clinicians with new data on the cellular and molecular biology of these disorders as well as their diagnosis and treatment. Topics The genomics and genetics of…